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Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation and metabolites found in Drosophila tissues.

The smallest p-values reveal tissues with the most significant changes in the pathway metabolites, between whole flies and individual tissues.

Tissue-Type Adult F/W p-value Adult M/W p-value Larvae/W p-value
Carcass 0.0000000000000000005066649136586746 0.000009122837133194657 0.00000000009321222296341816
MSpermatheca 0.0000000000000000000005437481024689602 nm nm
Midgut 0.00000000000000000000000000000000021549329603190085 0.00000000000000000000000000000000000000000000000000000000000000000049312528039712245 0.00000000000000000000032410612728403077
Trachea nm nm 0.0000000000000007547964564402889
Brain 0.0000000000000000000005602950022536967 0.0000000000020611141306964656 0.000000000000000007245754702002435
Tubules 0.0000000000012963151921001492 0.00000000009047228849743048 0.4736237802800366
VNC 0.00000000000000002519309593829214 0.000000000000005606491574294189 nm
Eye 0.0000000001408226641666704 0.0001197203916144643 nm
Salivary Gland 0.0000000000000028453437148974733 0.000000000000756788495155243 0.00000000000000000014232642909433567
Ovaries 0.0000000000000000011617857680103357 nm nm
Muscle 0.0000000000000003914501401921292 0.000000000000000013958670586072166 nm
VSpermatheca 0.000000000002688810389968331 nm nm
Accessory Gland nm 0.000000000000002612617941914715 nm
Hindgut 0.000000000000000000050808967014881015 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015988540053037053 0.00000000000000019020849770409662
Testes nm 0.0000012967207970182618 nm
Rectal Pad 0.00000000025389935706219166 0.000000022041572230710436 nm
Fat Body 0.00000000000000000016351928946937704 0.000000000000000000000027601108975071753 0.0000000000000000000038721371539184345
Hemolymph 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000010226364655639114 0.00000010774247771878758 0.0000000000000000026954290258220044
Crop 0.00000000000011358446166883054 0.000000000000000000000000000000000002595072676683299 nm
Head 0.000000027732203285566522 0.00000001984481286272004 nm
Heart 0.0000000000000000008408122914641899 0.000000019635797305455562 nm

In this diagram the overrepresentation shown as ReactomeH highlights compounds (with associated peaks) that are found in FlyMet

Selected Pathway